A NEW STUDY SHOWS GIRLS WHO ARE PRONE TO DEPRESSION AGE FASTER

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Girls who are stressed and prone to depression 'age faster than their peers'
Girls with a family history of depression respond differently to stress
Their bodies release higher levels of the hormone cortisol
They also have telomeres that are shorter by the equivalent of six years
Telomeres are caps on the end of chromosomes which are linked to ageing
Shorter telomeres are linked to premature death, and increase in disease
Exercise has been shown to delay telomere shortening, experts advised ..............continued below.................

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WHAT HAPPENS TO US WHEN WE ARE STRESSED?

Well this goes way back to the times when we were developing as humans and in early periods in history. The body's chemistry was designed to protect us with "The fight or flight response". For example man sees a big bear approach what does he do? he either tackles it or he runs off. Nature is very clever and gives us the capacity to do this. However in 2011 we no longer have the bears, wolves, etc. (ok some of you may) like of yesteryear we have different stresses. Your work colleagues or your neighbours may annoy you but you can't fight them, nor can you run away, but you can learn to deal and dissipate your stress levels so that it doesn't impinge on your health.

But firstly we need to deal with the science bit for if we understand the physiology of stress we're half way there to solving the impact stress has on our lives.

THE SCIENCE BIT

Deep within the brain we have an area known as the Hypothalamus (1), its the home of our moods and emotions and a very primitive part of the brain. The Hypothalamus is also the area that maintains equilibrium in our bodies and it maintains and regulates every bit of our body's chemistry. It is the area that controls the Endocrine system, it forms part of the Autonomic Nervous System and part of the Limbic System. It is Hypothalmus  that is the key to managing stress and all its detrimental effects on our mind and body. It is directly through this area that the holistic therapy Aromatherapy works and is managed by other holistic therapies.

 Since the Hypothalamus is the home of moods and emotions anything that affects these will influence the Hypothalamus, thus will have an effect on the body's equilibrium.

Now if we are stressed and modern stressors are not the same as those stressors we had as we were evolving as humans, they still have the same effect resulting in "the fight or flight response"

  

(1)The Role of the Hypothalamus

The Hypothalamus is the part of the brain that controls the endocrine system.

The Pituitary gland lies beneath the Hypothalamus  and it is this that controls the other endocrine glands.

The Hypothalamus receives information about the Homeostasis (balance) of the body, this is achieved by two means:

• The blood circulation i.e. temperature, blood glucose levels and hormone levels
• The nervous system i.e. The Autonomic Nervous system i.e. the part of the nervous system that regulates automatic functions e.g. breathing, heart rate etc. and mental and emotional states, our feelings: these influence ‘automatic responses’ e.g. ‘The fear, flight response’

The Hypothalamus responds to these changes by:

• Secreting Hormones (chemical messengers) that regulate hormones to be released by the anterior lobe of the pituitary
• The hypothalamus also directly releases hormones via the Posterior Lobe of the Pituitary , Vasopressin (ADH) and Oxytocin
• And by stimulating a nerve response to the ‘Central Nervous System’ (Brain & spinal Cord)

SO WHAT HAPPENS IN THE FIGHT OR FLIGHT RESPONSE?

Moods/emotions affect the hypothalamus, the hypothalamus evokes a reaction on the anterior lobe of the pituitary gland. The pituitary gland produces Adrenocorticotropic hormone this in turn targets the adrenal glands causing them to secrete Cortisone, Cortisone in turn effects the kidneys causing a rise in blood pressure by causing changes in the amount of salt secreted, this hormone causes the body to retain salt. Now remember the Hypothalamus one of its jobs is to maintain the body's equilibrium, it detects a rise in salt levels in the blood so to keep balance it causes the body to retain fluid, it is this retained fluid that increases blood pressure. At the same time, the Hypothalamus being part of the Central Nervous System evokes what is known as the Sympathetic Nervous System this diverts blood away from the digestive system and to lesser important body structures such as the skin and concentrates the blood to the heart, lungs and muscles. Simultaneously this nervous response influences the adrenal glands to produce Adrenalin and Noradrenalin, it is these hormones that induces vasoconstriction (reduces the blood supply) to the skin and peripheral tissues, thus also raising blood pressure.

Now this is putting it simply there are a few other processes also going on to increase blood sugar to give the body fuel to either run off or fight, Corticotrophic hormones influence the pancreas to secrete glucagon this has the opposite effect as insulin.

When the stress is over the Parasympathetic Nervous reverses the process again it is the Hyptholamus that instigates this.

Obviously its much more complex than this and I have focused on a few key hormones as it the action of these hormones that affects our well-being, the ageing process and blood pressure.

The fight or flight response was not designed to last forever it was meant ti instigate an action to deal with an aggressor, be it a wild animal or in a fight with an attacker therein lies the problem modern stressors tends to be work, work colleagues etc. the stress becomes long acting, this kind of reaction is fine in the short term but very detrimental to the body in the long term.

Take Cortisone, it has a damaging effect on specialised cells within the dermis (the skin), fibroblasts, these cells produce collagen and elastin, it is collagen and elastin that gives our skin elasticity and support. Adrenalin reduces blood supply to the peripheral tissues, such as the skin and hair, therefore, these structures do not receive adequate nourishment from the blood. So the effect of long term stress affects the skin resulting in ageing of the skin





Stress and how it affects us 

Stress The dictionary definition of stress is: a constraining or impelling force, effort or demand upon physical or mental energy. A stressor is a person or situation that makes you become stressed. We are more likely to suffer stress in society today than that of our ancestors. 70% of all illness to day is now directly attributed to stress. Modern society with all its pressures traffic congestion, over-crowding, noise, fears and general uncertainties about work, mortgages and family life present situation after situation where the state of stress is ever present. Stress is an everyday part of modern life, everyone experiences at sometime or another and everyday stresses are not necessarily harmful. A certain about of stress keeps us motivated and stimulated to make life more enjoyable and interesting. It is the effect of long-term stress that can be positively harmful to our bodies.

When do stress levels become harmful? 

The factors that seem to make any situation dangerously stressful are:

• Lack of predictability
• Lack of control
• Lack of outlets for frustration

For when these elements are present even simple situations can become stressful and produce a reaction that is completely out of proportion to the cause. It is not the situation but our reaction to it that creates the stress in our lives. The problem with us humans we have this tendency to dwell on the past and worry about the future and this takes our attention away from the present. Yet it is in the present moment that we have the greatest clarity to deal with any situation. We should enjoy our life in the present for in holding on to the past and holding back the future we create fear and ultimately stress. Growth in our lives is usually preceded by change the problem is handling change can be difficult in the short term and life-changing events such as:

• Bereavement
• Moving House
• Debt
• Ill Health
• Difficult Relationships
• Stressful Work
• Family Problems Have been identified as the most likely to cause negative or harmful stress.
Even positive events such as:
• Marriage
• Pregnancy
• A child starting school or University May cause you stress and can ultimately lead to illness.

Your personality and coping mechanisms will largely determine how you deal with these daily stresses and strains.

MPB (c)

CORTISOL OFTEN KNOWN AS THE 'STRESS HORMONE' 

Cortisol is a steroid hormone produced within the adrenal cortex in the adrenal glands, these are cone shaped organs sitting on top of the kidneys. It's a very important hormone and responsible for proper glucose metabolism, helping regulate blood pressure, has a part to play in insulin and blood sugar levels and is part of the inflammatory response. It's often known as the stress hormone but as you can see that's only part of its functions, and this is because it's secreted in higher levels as part of the 'Fight or Flight response'. When secreted in short bursts its beneficial to the body as due to it's actions, it helps mobilise energy reserves, heightens memory and lowers response to pain. This is how and why it's beneficial in the 'Fight and Flight response', it acts quickly and helps survival, however today's stresses are not the same as yesteryear and therein lies the problem.

When there is prolonged secretion of this hormone, when stress is on going, it causes blood sugar imbalances, affects bone density, causing it to decrease and also causes a decrease in muscle tissue. It raises blood pressure affects the body's immune system making us more susceptible to infection and leads to poor healing. It also causes shifts in body fat by increasing more fat around the abdominal areas and leads to higher levels of cholesterol.

The Hypothalamus & the Relationship to the Endocrine System in ‘Stress’

Below the flow chart illustrates how our minds' emotions and feelings trigger a reaction in the Hypothalamus to instigate what happens in the 'Fight or Flight' response. The Hypothalamus then in turn influences both the Autonomic Nervous System and the Endocrine system. This is fine short term it helps us cope in dangerous scenarios and was designed as a protective response, however the stresses of today are not those of yesteryear. No harm comes to our bodies in the short term, this is not the case in long term stress. All is not lost for there are ways we can influence the Hypothalamus to prevent the long term damaging effects of stress on our health. I shall be exploring this under Holistic Therapies. 

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ARTICLE BELOW IS FROM THE 'DAILY MAIL'

Girls who are stressed and prone to depression may age prematurely, a new study has found.

The research shows girls with a family history of depression respond to stressful situations by releasing higher levels of the hormone cortisol.

Scientists believe that in large amounts, cortisol can damage the immune system and organs, including the brain.

Girls with a history of depression also have telomeres that are shorter by the equivalent of six years in adults, researchers found. 

Girls prone to depression respond to stress by producing more of the hormone cortisol. They have shorter telomeres -  the caps on the end of chromosomes - which is a sign of ageing

Telomeres are caps on the ends of chromosomes, which get a little shorter every time a cell divides, or as a result of exposure to stress.

Telomere length is like a biological clock corresponding to age, getting shorter as adults grow up.

Previous studies have shown links between shorter telomeres and premature death, more frequent infections, and chronic diseases in adults.  

Professor Ian Gotlib, from Stanford University said the findings came as a surprise.

He said: 'I did not think that these girls would have shorter telomeres than their low-risk counterparts — they're too young.'

For the study, researchers recruited 10 to 14-year-old healthy girls with a family history of depression and compared them to healthy girls without that background. 

They measured the girls' response to stress tests, asking them to count backward from 100 by seven, and interviewing them about stressful situations.

Before and after the test, the team measured the girls' cortisol levels and also analysed DNA samples for telomere length.

'No one had examined telomere length in young children who are at risk for developing depression,' before the study, Professor Gotlib said. 

Healthy but high-risk 12-year-old girls had significantly shorter telomeres - a sign of premature aging. 

Exercise has been shown to delay telomere shortening in adults, so girls at high-risk girls should take exercise and learn other stress reduction techniques, experts advised

Professor Gotlib said: 'It's the equivalent in adults of six years of biological aging.

But he added that 'it's not at all clear that that makes them 18, because no one has done this measurement in children'.

Exercise has been shown to delay telomere shortening in adults, so girls at high-risk girls should learn stress reduction techniques, he advised.

Other studies show that neuro-feedback and attention bias training – which redirects attention toward the positive - appear promising.

Other investigators are studying techniques based on mindfulness training.

Professor Gotlib said he and colleagues are continuing to monitor the girls from the original study and it seems as though those with shorter telomeres are more likely to become depressed.

'It's looking like telomere length is predicting who's going to become depressed and who's not' he said.

The study was published in the journal Molecular Psychiatry.

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