The nasal spray that can tackle depression in just two hours
The spray, based on a natural brain chemical, could be effective within two hours, compared to several days for some of the most widely used antidepressant drugs.
The liquid is released at the top of the nose and is designed to penetrate the brain areas involved in mood.
A clinical trial is now under way looking at the feasibility of the treatment.
Researchers say future studies could look at the effects of the brain chemical in patients with other psychiatric disorders, such as post-traumatic stress disorder.
It is estimated that one in four women and one in ten men will require treatment for depression at some time in their lives.
One of the downsides of antidepressant pills is that they can take a long time to work — between two and eight weeks.
In a new trial at the Mount Sinai School of Medicine in New York, researchers are investigating the use of a nose spray containing a brain chemical called neuropeptide.
These are chemicals used by nerve cells in the brain to communicate with each other.
Some of the chemicals, and one in particular — neuropeptide Y — is thought to be involved in how the brain regulates behaviour and mood.
This compound is the most abundant peptide in the human brain, and is found in nerve fibres alongside another chemical called norepinephrine, which is thought to be involved in regulating mood and anxiety.
Previous research has also shown that stress leads to the release of the chemical, and a recent study by University of Michigan researchers, published in the Archives of General Psychiatry, found that people who have a genetic predisposition to have low neuropeptide levels may be at higher risk of developing depression.
However, nasal sprays can overcome this problem.
The upper part of the nose is like a back door into the brain because the nerves involved in smell provide a pathway straight into the central nervous system.
The new trial, which involves 15 volunteers aged 25 to 45, is designed to investigate how well the spray and neuropeptide Y work in the brain, and the effects will be compared with a placebo.
Researchers, who expect results in about two months, use an extra-powerful device to get the liquid as high as possible in the nose, into the area at the very top which is rich in nerves used for detecting smells.
Commenting on the research, a spokesperson from mental health charity Mind says: ‘This research is at an early stage and it remains to be seen whether this trial will lead to a new treatment.
‘It is important to recognise that alternative approaches to antidepressants, such as talking therapies and exercise, can also have positive results.’
No comments:
Post a Comment
Feed back and comments are always welcome and I look forward to your views and opinions, But please make them in English.
Sorry but Spam is automatically deleted as will unappropriated back links